Pharmacogenetic Testing

Pharmacogenetic
Testing

What if you could know that the medication prescribed for you was in fact, the right one?

RxIGHT genetic test may help do just that. With a simple cheek swab, which your pharmacist sends to our lab, we run your DNA using our state-of-the-art testing equipment that ensures 99.8% accuracy. The results are presented by your pharmacist in a report indicating which medications may be right and which to avoid.

RxIGHT includes:
  • The most comprehensive Pharmacogenetic test available
  • Results on more than 200 prescription and OTC medications
  • A personalized medication review with a pharmacist
  • Test results report
  • Laboratory services at no extra cost
  • HIPAA compliant privacy and security

Both clinicians and patients know that drugs can cause side effects. However, not all patients experience side effects. Variability in drug response is due to many factors including age, weight, number of medications taken and overall health. Genetic variation is also a reason that a patient may experience an adverse reaction to a drug. Pharmacogenetics studies the way that variations in a patient’s genetic makeup affect the metabolism of drugs.
This test examines specific genes associated with drug metabolism to determine whether an individual’s inherited characteristics may cause side effects, toxicity or result in no therapeutic value.

To avoid adverse reactions, doctors often use a trial and error method to find appropriate medications for patients. Pharmacogenetic testing provides important information about which medicines may cause unpleasant side effects. Testing also helps clinicians find doses of medications that are appropriate for a patient’s genetic characteristics.

Variations in Individual Response to Medications

Genetic variants affect the rate of assimilation of a drug by the body. Poor metabolism of a drug can cause adverse effects because the drug stays in the body too long. Ultra-rapid metabolism may result in no benefit from the drug because it is eliminated too quickly.

Rxight™ genetic testing examines 18 genes that have known associations with drug metabolism, including common enzymes involved in drug metabolism. A sample of a patient’s DNA is taken by a certified pharmacist and sent to MD Labs for analysis. A detailed report, included in the cost, is provided to each patient and interpreted by the pharmacist. The pharmacist will consult with clinicians to ensure that the prescribed medication therapy regimen is best suited for the patient’s genetic characteristics. Doctors can select medicines and doses that may result in fewer side effects and provide better therapeutic value. Patients are more likely to take their medicine when they know that the potential for side effects is reduced. Better adherence to a drug therapy program helps maintain health.

Pharmacogenetic Testing

Curemed

Why Is Testing Important?

When prescribing or taking medications, there isn’t room for error.

But that’s the problem patients, pharmacists and providers face every time a prescription is written: the possibility that the medication won’t work, or that it will have a toxic or life-threatening side effect. Prescribers must rely on general population statistics to select effective medications for their patient and hope their patient isn’t part of the cohort that experiences dangerous side effects or adverse drug reactions.  The Rxight test gives providers and pharmacists specific data to help make evidence-based decisions personalized to the patient’s genetic profile.

The Importance of Pharmacogenetic Testing

Employing DNA drug sensitivity testing to screen medications before therapy helps patients avoid drugs that won’t process and/or metabolize well, and instead allows the physician to prescribe the right medication from the beginning. This can help accelerate the benefits from medications, reduce wasted time and expense on ineffective medications, and possibly even save lives.

Medication Adherence

Poor medication adherence is an increasing concern in the medical community, especially for patients who are diagnosed with chronic conditions or diseases. This is because patient behavior related to the proper use of prescribed medications and drug treatment plans varies from individual to individual based on a bevy of factors. Individual patients who have a high degree of confidence in the medications prescribed by a healthcare provider typically have a high level of medication adherence, meaning prescriptions are taken as directed in the proper dosage for the recommended amount of time. Alternatively, patients who lack confidence in the safety or efficacy of a prescribed medication generally fail to follow the regimen of care as closely as providers deem necessary for successful drug treatment (source).

Pharmacogenetic testing, also known as PGx testing, provides healthcare providers a sound method to reduce the potential for poor medication adherence by increasing patient confidence in prescribed drug treatments. Pharmacogenetics offers additional insight into how patients’ genetic profiles may affect the outcome of or reaction to specific medications. Pharmacogenetic testing lays part of the groundwork for precision care, based on the individual needs and genetic makeup of a single patient.

Armed with pharmacogenetic testing results, providers can speak with more authority on an individual patient’s drug treatment plan, ultimately leading to increased patient confidence and medical adherence.

Reduced Medical Costs

High medical costs are directly correlated to incorrect or inefficient drug treatment plans in a number of individual patient cases. Patients who go through several rounds of various prescribed medications in an attempt to find the right fit have a higher propensity to spend more on care. Higher costs are the result of an increased number of healthcare provider visits, multiple costly prescriptions and the need for treatment related to adverse drug reactions or side effects of inappropriate or ill-suited drug treatment recommendations (source).

Knowing how one’s genetic profile and related metabolism of certain medications starkly decreases the possibility of providing a drug treatment plan with unwanted effects. Logically, PGx testing prior to prescribing certain medications has the potential to reduce the total expenses associated with ineffective health care for patients by reducing the need for treatment plan changes.

Optimal Dosing

Prescription medications are tested thoroughly prior to being released for approved use in the treatment of diseases and conditions, but the research in pharmaceutical development has its limits. Drug manufacturers and medical researchers use a sample group of individuals to ascertain whether a drug is effective in treating specific ailments, and decisions about efficacy are based on that population set. While a medication in a specific dose may be effective for a portion of the population based on that truncated research group, not every individual will experience similar results from what is deemed the standard dosage of a prescribed medication (source). 

Pharmacogenetic testing provides a direct path to individualized treatment based on the genetic traits present in each patient. By utilizing precision medicine backed by pharmacogenetics, providers have the ability to pinpoint the optimal dosage of certain medications that have the greatest potential to result in treatment success for patients.

Reduced Adverse Effects

According to the Food and Drug Administration, adverse drug reactions, or ADRs, are one of the leading causes of mortality and morbidity in the healthcare system, ahead of pulmonary disease, diabetes, accidents and automobile deaths. The number of adverse drug reactions is slated to increase as more medications become available in the market, and as more healthcare providers implement drug treatment plans that consist of more than four prescription medications. 

While some side effects are a challenge to avoid, some ADRs are the result of drug treatment plans that are not well-suited for an individual patient. When providers have a better understanding of how a patient’s genetic profile may interact with specific medications, a more effective drug treatment plan can be set in motion. The use of PGx testing leads to fewer adverse side effects experienced by individuals within the healthcare system, based on a more effective, personalized plan of treatment.

Tests for the following medications: Adderall, Dexedrine, ProCentra, Zenzedi, Vyvanse, Focalin, Concerta, Daytrana, Metadate, Methulin, Quillivant, Ritalin, Kapvay, Intuniv, Tenex, Budeprion, Burproban, Forfivo, Wellbutrin

This identifies key information about your genetic response to pain medications, helping you make the best treatment decision possible:

Buprenorphine, Buprenorphine/Naloxone, Carisoprodol, Codeine, Diclofenec, Fentanyl, Hydrocodone, Hydromorphone, Ibuprofen, Ketolorac, Meloxicam, Meperidine, Methadone, Morphine, Naloxone, Naltrexone, Naproxen, Oxycodone, Oxymorphone, Tramadol.

Know if Plavix is right for you. It is concerning that 3 in 10 patients have a genetic makeup that keeps them from responding to Plavix as intended.

They can help you determine if your genetic makeup makes you susceptible to myopathy while taking Zocor.

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